The process of mammalian mitochondrial protein synthesis
نویسندگان
چکیده
منابع مشابه
Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones.
The effects of a variety of oxazolidinones, with different antibacterial potencies, including linezolid, on mitochondrial protein synthesis were determined in intact mitochondria isolated from rat heart and liver and rabbit heart and bone marrow. The results demonstrate that a general feature of the oxazolidinone class of antibiotics is the inhibition of mammalian mitochondrial protein synthesi...
متن کاملMitochondrial protein synthesis: Figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation
Mitochondrial protein synthesis is essential for all mammals, being responsible for providing key components of the oxidative phosphorylation complexes. Although only thirteen different polypeptides are made, the molecular details of this deceptively simple process remain incomplete. Central to this process is a non-canonical ribosome, the mitoribosome, which has evolved to address its unique m...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولInhibitors of mammalian protein synthesis.
The number of antibiotics active on eukaryotic ribosomes has been considerably increased in the last few years. Some of them are active only in eukaryotic ribosomes whereas some others are active on prokaryotic as well as eukaryotic ribosomes (Table 1). There is ample evidence suggesting a sirnilar mechanism for the elongation cycle by prokaryotic and eukaryotic ribosomes. This evidence is main...
متن کاملDisorders of mitochondrial protein synthesis.
Mitochondrial tRNA gene mutations, including heteroplasmic deletions that eliminate one or more tRNAs, as well as point mutations that may be either hetero- or homoplasmic, are associated with a wide spectrum of human diseases. These range from rare syndromic disorders to cases of commoner conditions such as sensorineural deafness or cardiomyopathy. The disease spectrum of mutations in a given ...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2016
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-016-2456-0